Open Access Research article

A novel reporter system for neutralizing and enhancing antibody assay against dengue virus

Ke-Yu Song12, Hui Zhao1, Zhen-You Jiang2, Xiao-Feng Li1, Yong-Qiang Deng1, Tao Jiang1, Shun-Ya Zhu1, Pei-Yong Shi3, Bo Zhang4, Fu-Chun Zhang5, E-De Qin1 and Cheng-Feng Qin1*

  • * Corresponding author: Cheng-Feng Qin qincf@bmi.ac.cn

  • † Equal contributors

Author Affiliations

1 Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China

2 Department of Microbiology and Immunology, School of Medicine Jinan University, Guangzhou 510632, China

3 Novartis Institute for Tropical Diseases, Singapore 138670, Singapore

4 State Key Laboratory of Virology, Wuhan Institute of Virology, CAS, Wuhan 430072, China

5 Guangzhou No.8 People’s Hospital, Guangzhou 510060, China

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BMC Microbiology 2014, 14:44  doi:10.1186/1471-2180-14-44

Published: 18 February 2014

Additional files

Additional file 1: Figure S1:

Growth curve of Luc-DENV on BHK-21 cells expressed by luciferase activity. Cells were infected with virus at MOI of 0.5, collected and lysed at the indicated time points to measure the luciferase activities. Each data point represents the mean obtained in three separate assays with SD (indicated by bars).

Format: TIFF Size: 56KB Download file

Open Data

Additional file 2: Figure S2:

Growth curve of Luc-DENV on K562 cells expressed by luciferase activity. Cells were infected with virus at MOI of 0.5, collected and lysed at the indicated time points to measure the luciferase activities. Each data point represents the mean obtained in three separate assays with SDs (indicated by bars).

Format: TIFF Size: 51KB Download file

Open Data