Table 4

Streptomycin and ethambutol resistance-associated mutations detected in M. tuberculosis study isolates
Resistance to Gene N° and type of isolates tested N° of isolates with indicated genotype Nucleotide change Amino acid change
Streptomycin rpsL 27 SMR 2 43AAG → AGG Lys → Arg
100 SMS 0 WT NA
gidB 27 SMR 1 138GCG → CCG Ala → Pro
1 79TTG → TGG Leu → Trp
1 75CCG → TCG Pro → Ser
1 48CAT → AAT His → Asn
1 36GTG → GGG Val → Gly
100 SMS 3 205GCA → GCG Ala → Ala*
3 16CTT → CGT Leu → Arg
Ethambutol embC 2 EMBR 0 WT NA
100 EMBS 3 -20A → C NA
3 -230A → C NA
embA 2 EMBR 0 WT NA
100 EMBS 3 330CTG → TTG Leu → Leu*
embB 2 EMBR 100 EMBS 1 306 Met → Val
0 WT NA

*: synonymous mutation; NA = not applicable; WT = wild type; SMR = streptomycin resistant isolate; SMS = streptomycin sensitive isolate; EMBR = ethambutol resistant isolate; EMBS = ethambutol sensitive isolate; N° = Number.

Tekwu et al.

Tekwu et al. BMC Microbiology 2014 14:113   doi:10.1186/1471-2180-14-113

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