Open Access Highly Accessed Research article

Antimicrobial activity of pure platelet-rich plasma against microorganisms isolated from oral cavity

Lorenzo Drago12*, Monica Bortolin3, Christian Vassena1, Silvio Taschieri3 and Massimo Del Fabbro3

Author affiliations

1 Laboratory of Clinical Chemistry and Microbiology, I.R.C.C.S. Galeazzi Orthopaedic Institute, Via R. Galeazzi 4, Milan, 20161, Italy

2 Department of Biomedical Sciences for Health, University of Milan, Milan, Italy

3 Department of Biomedical, Surgical and Dental Sciences, I.R.C.C.S. Galeazzi Orthopaedic Institute, University of Milan, Milan, 20161, Italy

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Citation and License

BMC Microbiology 2013, 13:47  doi:10.1186/1471-2180-13-47

Published: 25 February 2013



Autologous platelet concentrates (PCs) have been extensively used in a variety of medical fields to promote soft and hard tissue regeneration. The significance behind their use lies in the abundance of growth factors in platelets α-granules that promotes wound healing. In addition, antibacterial properties of PCs against various bacteria have been recently pointed out. In this study, the antimicrobial effect of pure platelet-rich plasma (P-PRP) was evaluated against oral cavity microorganisms such as Enterococcus faecalis, Candida albicans, Streptococcus agalactiae, Streptococcus oralis and Pseudomonas aeruginosa. Blood samples were obtained from 17 patients who underwent oral surgery procedures involving the use of P-PRP. The antibacterial activity of P-PRP, evaluated as the minimum inhibitory concentration (MIC), was determined through the microdilution twofold serial method.


P-PRP inhibited the growth of Enterococcus faecalis, Candida albicans, Streptococcus agalactiae and Streptococcus oralis, but not of Pseudomonas aeruginosa strains.


P-PRP is a potentially useful substance in the fight against postoperative infections. This might represent a valuable property in adjunct to the enhancement of tissue regeneration.

Platelet concentrate; Oral infection; Antimicrobial effect; Minimum inhibitory concentration; Oral cavity