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Open Access Research article

Hyperosmotic response of streptococcus mutans: from microscopic physiology to transcriptomic profile

Chengcheng Liu1, Yulong Niu2, Xuedong Zhou1, Keke Zhang1, Lei Cheng1, Mingyun Li1, Yuqing Li1, Renke Wang1, Yi Yang2 and Xin Xu1*

Author Affiliations

1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China

2 Key Lab of Bio-resources and Eco-environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, PR China

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BMC Microbiology 2013, 13:275  doi:10.1186/1471-2180-13-275

Published: 1 December 2013

Additional files

Additional file 1:

Heat map of different expressed genes of Streptococcus mutans UA159 in response to short-term hyperosmotic stress. Transcript enrichment is encoded in the heat map from low (blue) to high (red). Transcripts that show similar expression patterns are clustered together, as indicated on the top of the heat map. Gene IDs and their associated gene annotations are shown on the right of the heat map.

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Open Data

Additional file 2:

Quality control of RNA samples by Agilent 2100 Bioanalyzer. (A) Electrophoresis files, and (B) The electropherogram of the sample well window for total RNA. The RNA Integrity Number (RIN) of all samples was > 7.0.

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Open Data

Additional file 3:

Oligonucleotide primers used in quantitative RT-PCR.

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Open Data