Table 5

Gene expression (6 h) under hyphae inducing culture conditions (medium supplemented with 10% fetal calf serum, with culture incubation at 37ºC)
Gene Untreated C. albicans Amphotericin B KSL-W 25 μg/ml KSL-W 100 μg/ml
Fold change1 Fold change1 p-value2 Fold change1 p-value2 Fold change1 p-value2
SAP2 0.99 8.17 0.009 0.7 0.2 1.31 0.02
SAP4 0.96 2.58 0.03 0.73 0.04 0.72 0.04
SAP5 1.00 0.72 0.007 0.83 0.0004 0.56 0.006
SAP6 1.00 4.01 0.02 0.58 0.01 0.68 0.04
EAP1 1.00 6.36 0.001 0.44 0.008 0.73 0.003
EFG1 1.00 1.78 0.048 0.31 < 0.0001 0.47 0.01
NRG1 1.00 3.97 0.0005 0.37 0.001 0.37 0.05
HWP1 1.00 0.008 < 0.001 0.09 0.001 0.03 < 0.0001

1Fold change was calculated by PCR product of the gene of interest/the PCR product of ACT1 (the house keeping gene), and normalized to the negative control of untreated C. albicans where the expression was considered equal to 1.

2P-values were obtained after comparison of test to negative control (untreated C. albicans).

Theberge et al.

Theberge et al. BMC Microbiology 2013 13:246   doi:10.1186/1471-2180-13-246

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