Infection with Salmonella decreases the expression of FXR-target genes in the ileum. (A) Relative levels of Fabp6, Nr0b2 and Osta transcripts in the ileum of mice orally infected with Salmonella typhimurium SL1344. Animals were arbitrarily grouped into low, medium and high infection levels (100-103, 104-105 and >106 cfu/mg, respectively roughly corresponding to 72, 96 and 120 hours post-infection; UI: uninfected). (B)Fgf15 transcript levels in the ilea of uninfected mice fed 5% cholestyramine diet. Data by qPCR, **p < 0.01; ***p < 0.001; ****p < 0.0001.
Romain et al. BMC Microbiology 2013 13:238 doi:10.1186/1471-2180-13-238