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Open Access Research article

Cis-2-dodecenoic acid signal modulates virulence of Pseudomonas aeruginosa through interference with quorum sensing systems and T3SS

Yinyue Deng12*, Calvin Boon1, Shaohua Chen2, Amy Lim1 and Lian-Hui Zhang12*

Author Affiliations

1 Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore, 138673, Singapore

2 College of Natural Resources and Environment, South China Agricultural University, Guangzhou, People's Republic of China

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BMC Microbiology 2013, 13:231  doi:10.1186/1471-2180-13-231

Published: 18 October 2013

Additional files

Additional file 1: Figure S1:

Inhibition of exogenous addition of BDSF on the production of 3-oxo-C12-HSL (A), PQS (B) and C4-HSL (C) of P. aeruginosa PA14. Figure S2. Inhibitory effect of BDSF on the production of extracellular protease (A) and pyocyanin (B) of PA1396 deletion mutant of P. aeruginosa PA14. The data are the means of three repeats and error bars indicate the standard deviations. Figure S3. Inhibitory effect of BDSF on T3SS of psrA deletion mutant of P. aeruginosa PA14, as determined by using PexsCEBA-lacZ fusion reporter strain. The data are the means of three repeats and error bars indicate the standard deviations. Table S1. Chemical structures of BDSF and its derivatives. Table S2. PCR primers used in this study.

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