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Open Access Research article

Tetracycline accelerates the temporally-regulated invasion response in specific isolates of multidrug-resistant Salmonella enterica serovar Typhimurium

Brian W Brunelle1*, Shawn MD Bearson1 and Bradley L Bearson2

Author Affiliations

1 Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA

2 Agroecosystems Management Research Unit, National Laboratory for Agriculture and the Environment, ARS, USDA, Ames, IA 50010, USA

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BMC Microbiology 2013, 13:202  doi:10.1186/1471-2180-13-202

Published: 11 September 2013

Additional files

Additional file 1: Table S1:

Invasion and gene expression data. Four biological replicates were performed for each condition tested, and the table lists the average, standard error of the mean, and significance compared to the control. Each of the eight isolates (1434, 5317, 752, 1306, 4584, 290, 360, and 530) was tested at four different tetracycline concentrations (0, 1, 4, and 16 μg/ml) during two different growth phases (early- and late-log) for changes in invasion, as well as changes in gene expression at up to eight different loci (hilA, prgH, invF, tetA, tetB, tetC, tetD, tetG). Invasion data are listed as percentages, and the expression data are log2-fold changes. Significance is indicated for P < 0.05 (*), P < 0.01 (**), and P < 0.001 (***).

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