Partial neutralizing activities of mAb 4D10 and anti-PL10 sera. Serial 2-fold dilutions of antibody were mixed with approximately 50 PFU DENV and incubated for 1 h at 37°C. Neutralizing activities were evaluated by plaque reduction assay using BHK21 cells. Both 4D10 (A) and anti-PL10 sera (B) exhibited partial neutralizing activities against standard DENV-4 and imDENV2. Data are expressed as means of at least three independent experiments. The error bars represent standard deviations (SD). If there is no error bar, it is not that no variations among three independent experiments but that the variations are too small to show in the figure.
Luo et al. BMC Microbiology 2013 13:194 doi:10.1186/1471-2180-13-194