Table 2

Time course: KEGG cellular pathways and gene ontology

Time

KEGG cellular pathway name

IF

GO up-regulated genes

GO down-regulated genes


0.5

No significant genes

No significant genes

No significant genes


1

Epithelial cell signaling in Helicobacter pylori infection

16.6

No significant GO

No significant genes

Cytokine-cytokine receptor interaction

8.1

Bladder cancer

7.5

Toll-like receptor signaling pathway

6.6

Base excision repair

6.0

Primary immunodeficiency

5.9

Pathways in cancer

5.4


3

Epithelial cell signaling in Helicobacter pylori infection

17.8

anti-apoptosis

No significant GO

Pathways in cancer

16.9

regulation of retroviral genome

Small cell lung cancer

14.2

replication

MAPK signaling pathway

14.2

T-helper 1 cell differentiation

Apoptosis

12.5

negative regulation of LPS-mediated signaling pathway

Adipocytokine signaling pathway

12.3

negative regulation of smooth muscle cell migration

Prostate cancer

11.4

regulation of MAP kinase activity chemotaxis

Toll-like receptor signaling pathway

11.1

protein amino acid dephosphorylation

T cell receptor signaling pathway

10.5

neutrophil activation

B cell receptor signaling pathway

9.9

entrainment of circadian clock


6

Phosphatidylinositol signaling system

32.2

anti-apoptosis

No significant GO

Epithelial cell signaling in Helicobacter pylori infection

15.5

regulation of retroviral genome

Small cell lung cancer

14.2

replication

Pathways in cancer

12.4

T-helper 1 cell differentiation

Apoptosis

11.6

neutrophil activation

Adipocytokine signaling pathway

10.1

negative regulation of I-kappaB

Toll-like receptor signaling pathway

8.9

kinase/NF-kB cascade

MAPK signaling pathway

8.7

induction of positive chemotaxis

Bladder cancer

8.5

myeloid dendritic cell differentiation

B cell receptor signaling pathway

8.3


12

Leukocyte transendothelial migration

309.7

cell cycle arrest

response to unfolded protein

Cell adhesion molecules (CAMs)

75.4

amino acid transport

S-adenosylmethionine biosynthetic process

DNA replication

25.0

positive regulation of transcription

Cell cycle

20.0

response to stress

Pathways in cancer

19.4

regulation of MAP kinase activity

p53 signaling pathway

17.0

Antigen processing and presentation

15.7

MAPK signaling pathway

13.2

Small cell lung cancer

12.2

Circadian rhythm

11.9


24

Leukocyte transendothelial migration

80.3

keratinocyte differentiation

cholesterol biosynthetic process

Cell cycle

24.4

amino acid transport

response to unfolded protein

p53 signaling pathway

20.9

keratinization

isoprenoid biosynthetic process

Circadian rhythm

18.6

angiogenesis

creatine biosynthetic process

DNA replication

18.0

apoptosis

response to oxidative stress

Adherens junction

16.1

response to stress

Pathways in cancer

14.9

cell cycle arrest

Nucleotide excision repair

14.3

pyrimidine nucleotide metabolic

Ubiquitin mediated proteolysis

14.2

process

Phosphatidylinositol signaling system

13.7

induction of positive chemotaxis


Significantly impacted KEGG cellular pathways and enriched Gene Ontology terms (biological processes only) (p < 0.05) at different time points following co-culture of H. pylori and AGS cells. Top 10 pathways/ontologies included where number exceeds 10. IF = impact factor

Eftang et al. BMC Microbiology 2012 12:9   doi:10.1186/1471-2180-12-9

Open Data