Simvastatin prophylaxis decreases histopathology and vascular leakage.A) Representative micrographs of Hematoxylin- and Eosin-stained lung sections from mice 42 h after infection. Note that the high statin fed mice exhibit reduced cellularity and vascular hemorrhage. Original magnification, 10X. B) Vascular integrity was determined by assessing the amount of albumin present in the BAL fluid by ELISA prior to and following infection (n = 3/group for uninfected and n = 6/group for infected mice). Data are presented as the mean ± SEM. Statistics were determined by a two-tailed student’s t-test. P < 0.05 was considered significant in comparison to Control fed mice.
Boyd et al. BMC Microbiology 2012 12:73 doi:10.1186/1471-2180-12-73