Figure 6.

A model for QS regulation mechanism via the RND-type efflux pump MexAB-OprM. (a) MexAB-OprM extrudes 3-oxo-Cn-HSLs and controls the accessibility of non-cognate acyl-HSLs to LasR in P. aeruginosa QS-regulation. (b) In the P. aeruginosa MexAB-OprM mutant, non-cognate 3-oxo-Cn-HSLs activate LasR. Non-cognate 3-oxo-Cn-HSLs-LasR complexes induce the wrong QS regulation.

Minagawa et al. BMC Microbiology 2012 12:70   doi:10.1186/1471-2180-12-70
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