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Role of Mycobacterium tuberculosis pknD in the Pathogenesis of central nervous system tuberculosis

Nicholas A Be12, William R Bishai1 and Sanjay K Jain123*

Author Affiliations

1 Center for Tuberculosis Research, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, Maryland, 21287, USA

2 Department of Pediatrics, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, Maryland, 21287, USA

3 Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, 1550 Orleans Street, Baltimore, Maryland, 21287, USA

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BMC Microbiology 2012, 12:7  doi:10.1186/1471-2180-12-7

Published: 13 January 2012

Additional files

Additional file 1:

M. tuberculosis transposon disruption mutants screened for attenuation in the guinea pig model of central nervous system tuberculosis. 398 transposon mutants were selected for pooled infection in the guinea pig model. Each mutant listed was screened for attenuation in the central nervous system.

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