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Open Access Highly Accessed Research article

Correlation of intestinal microbiota with overweight and obesity in Kazakh school children

Peiru Xu12*, Min Li12, Jihong Zhang1 and Tao Zhang3

Author Affiliations

1 Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, Xinjiang Uyghur Autonomous Region 840054, People’s Republic of China

2 Xinjiang Evidence-based Medicine Research Institute, 137 Liyushan South Road, Urumqi, Xinjiang, Uyghur Autonomous Region 830054, People’s Republic of China

3 Department of Urology, Second Affiliated Hospital of Xinjiang Medical University, 38 nanhu East Road, Urumqi, Xinjiang Uyghur Autonomous Region, 830063, People’s Republic of China

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BMC Microbiology 2012, 12:283  doi:10.1186/1471-2180-12-283

Published: 28 November 2012

Abstract

Background

This study sought to investigate a possible correlation between the intestinal microbiota, Bacteroidetes and Firmicutes, and obesity in Kazakh school children, aged 7–13 (n = 175).

Results

Obese subjects had significantly greater systolic blood pressure, waist and hip circumference, as well as HOMA-IR as compared to normal and overweight participants. In addition, Bacteroides copy number and Bact/Firm ratios were significantly lower in the obese group as compared to the normal and overweight groups (P < 0.0167). This difference is only significant in girls, but not in boys when stratified by gender. Furthermore, a negative correlation between BMI and Bacteroidetes copy number (r = −0.18, P = 0.017) as well as Bact/Firm (r = −0.22, P = 0.003) was observed.

Conclusion

An association between reduced gut Bacteroidetes and Bact/Firm ratio with obesity in female Kazakh children was identified. Further studies are necessary to elucidate the mechanism behind these changes as well as the value of determining their presence for predicting obesity.

Keywords:
Obesity, Bacteroidetes; Firmicutes; Kazakh