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Open Access Research article

Clinical and microbiological characterization of Staphylococcus lugdunensis isolates obtained from clinical specimens in a hospital in China

Chaojun Liu1, Dingxia Shen1*, Jing Guo2, Kaifei Wang1, Huan Wang1, Zhongqiang Yan1, Rong Chen1 and Liyan Ye1

Author Affiliations

1 Department of Clinical Microbiology, General Hospital of The People’s Liberation Army, No. 28 Fu Xing Road, Hai Dian District, Beijing 100853, China

2 Clinical Laboratory, The 261st Hospital of The People’s Liberation Army, Beijing, China

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BMC Microbiology 2012, 12:168  doi:10.1186/1471-2180-12-168

Published: 6 August 2012

Abstract

Background

Several reports have associated Staphylococcus lugdunensis with the incidence of severe infection in humans; however, the frequency and prevalence of this microorganism and thus the propensity of its antimicrobial drug resistance is unknown in China. The objective of the current study was to determine the prevalence of Staphylococcus lugdunensis among six hundred and seventy non-replicate coagulase negative Staphylococcus (CoNS) isolates collected in a 12-month period from clinical specimens in the General Hospital of the People’s Liberation Army in Beijing, China.

Results

Five (0.7%) of the 670 isolates of CoNS were identified as S. lugdunensis. Whereas three isolates were resistant to erythromycin, clindamycin, and penicillin and carried the ermC gene and a fourth one was resistant to cefoxitin and penicillin and carried the mecA gene, one isolate was not resistant to any of the tested antimicrobials. Pulse field gel electrophoretic analysis did not reveal widespread epidemiological diversity of the different isolates.

Conclusion

Hence, even though S. lugdunensis may be yet unrecognized and undefined in China, it still might be the infrequent cause of infection and profound multi-drug resistance in the same population.

Keywords:
Staphylococcus lugdunensis; Coagulase-negative staphylococci; Antibiotic resistance; Pulsed-field gel electrophoresis; mecA; ermC