Open Access Highly Accessed Research article

The streptococcal collagen-like protein-1 (Scl1) is a significant determinant for biofilm formation by group a Streptococcus

Heaven A Oliver-Kozup1, Meenal Elliott1, Beth A Bachert7, Karen H Martin23, Sean D Reid4, Diane E Schwegler-Berry5, Brett J Green6 and Slawomir Lukomski1*

Author Affiliations

1 Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV 26506, USA

2 Mary Babb Randolph Cancer Center, West Virginia University School of Medicine, Morgantown, WV 26506, USA

3 Microscope Imaging Facility, West Virginia University School of Medicine, Morgantown, WV 26506, USA

4 Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA

5 Pathology and Physiology Research Branch, National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA

6 Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA

7 Beth A. Bachert was enrolled in Biomedical Sciences Graduate Programs, West Virginia University Health Sciences Center

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BMC Microbiology 2011, 11:262  doi:10.1186/1471-2180-11-262

Published: 14 December 2011

Additional files

Additional file 1:

Figure S1. Biofilm formation by the isogenic wild-type and scl1-inactivated GAS strains. The figure shows gallery views and X-Y orthogonal Z-stack views of GFP-expressing GAS biofilms at 24 h rendered by confocal laser scanning microscopy (CLSM). Figure S2. Biofilm formation by the wild-type and Scl1-expressing L. lactis strains. The figure shows gallery views and X-Y orthogonal Z-stack views of GFP-expressing L. lactis biofilms at 24 h rendered by CLSM.

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