Open Access Highly Accessed Research article

A novel bacteriophage Tail-Associated Muralytic Enzyme (TAME) from Phage K and its development into a potent antistaphylococcal protein

Vivek Daniel Paul12, Sanjeev Saravanan Rajagopalan1, Sudarson Sundarrajan1, Shilpa E George1, Jiya Y Asrani1, Renjith Pillai13, Ravisha Chikkamadaiah1, Murali Durgaiah1, Bharathi Sriram1* and Sriram Padmanabhan14

Author Affiliations

1 Gangagen Biotechnologies Pvt Ltd., No. 12, 5th Cross, Raghavendra Layout, Tumkur Road, Yeshwantpur, Bangalore 560 022, India

2 Department of Molecular Genetics, University of Toronto,1 King's College Circle, Toronto, ON-M5S 1A8, Canada

3 Lab Technologist, Pulmonary research, 559, Heritage Medical Research Center Dept of Medicine,112 St and 87 Ave, Edmonton, Alberta-T6G2S2, Canada

4 Lupin Limited, Biotechnology R & D, Gat #1156, Ghotawade Village, Mulshi Taluka, Pune-411042, India

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BMC Microbiology 2011, 11:226  doi:10.1186/1471-2180-11-226

Published: 11 October 2011

Additional files

Additional file 1:

Table S1: Global panel of Clinical isolates received from The Public Health Research Institute Center (PHRI), New Jersey.

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Additional file 2:

Table S2: Other strains used in the study.

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Additional file 3:

Figure S1: Alignment of Phage K ORF56 with other CHAP domain proteins.

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Additional file 4:

Figure S2: Bactericidal activity of ORF56.

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Additional file 5:

Table S3: MRSA colonization status of rat nares 3 days after instillation of USA300.

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