Open Access Highly Accessed Open Badges Research article

Lysis-deficient phages as novel therapeutic agents for controlling bacterial infection

Vivek Daniel Paul12, Sudarson Sundarrajan1, Sanjeev Saravanan Rajagopalan1, Sukumar Hariharan1, Nanjundappa Kempashanaiah13, Sriram Padmanabhan14, Bharathi Sriram1* and Janakiraman Ramachandran1

Author Affiliations

1 Gangagen Biotechnologies Pvt Ltd, No. 12, 5th Cross, Raghavendra Layout, Tumkur Road, Yeshwantpur, Bangalore-560 022, India

2 Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada

3 Department of Animal Husbandry, Veterinary Dispensary, Yediyur, Kunigal Taluk, Tumkur- 572142, India

4 Lupin Limited, Biotechnology R & D, Gat #1156, Ghotawade Village, Mulshi Taluka, Pune-411042, India

For all author emails, please log on.

BMC Microbiology 2011, 11:195  doi:10.1186/1471-2180-11-195

Published: 31 August 2011

Additional files

Additional file 1:

Figure S1 - Genome map of phage P954. Phage P954 genome is similar in organization to other known temperate staphylococcal phages. The organization of the genome is modular, with genes involved in lysogeny, replication, DNA packaging, tail assembly, and lysis arranged sequentially).

Format: DOC Size: 69KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 2:

Table S1 - Comparison of host range of parent and endolysin deficient phage P954. The host range of both the phage were same on a panel of 20 phage-sensitive and phage-resistant isolates.

Format: DOCX Size: 13KB Download file

Open Data