Table 1

The profile of proinflammatory cytokine and chemokine secretion of iDCs in response to C. parapsilosis

iDC (24 h)


(pg/ml)

unstimulated

Cp wt

Cp lip-/-


IL-1 α

9.38(8.20-11.19)

10.01 (8.34-11.17)

23.60# (19.88-26.74)

IL-6

175.77 (48.34-252.62)

3059.61 (1689.8-5880.12)

5636.54# (2792.25-7915.07)

TNF α

74.36 (55.71-115.78)

624.47 (522.57-736.08)

2836.59# (2822.29-3147.02)

CXCL8

794.23 (162.80-1226.77)

3622.8 (2047-5297.31)

3023.9 (1226.41-5297.31)


iDC (48 h)


(pg/ml)

unstimulated

Cp wt

Cp lip-/-


IL-1 α

7.85 (5.05-12.31)

15.45 (8.34-21.56)

22.14 (19.88-26.74)

IL-6

3573.23 (3201.12-4752.01)

5238.9 (3767.13-6082.85)

6968.16# (5398-8938.58)

TNF α

154.92 (115.71-194.82)

2342.12 (649.76-4333.62)

3947.27# (2433.01-5393.78)

CXCL8

1103.05 (656.02-1473.77)

1615.33 (942.11-1756.85)

1824.31 (1226.41-2491.06)


n = 8 independent blood donors

Immature dendritic cells were stimulated with C. parapsilosis wild type (Cp wt), lipase deficient (Cp lip-/-) cells or left unstimulated. Secretion of IL-1α, IL-6, TNFα or CXCL8 by iDCs was determined by Luminex analyzer or ELISA at 24 h and 48 h post-infection. †: medians (interquartile ranges) # p < 0.05

Nagy et al. BMC Microbiology 2011 11:122   doi:10.1186/1471-2180-11-122

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