Table 1

Formerly and newly identifiedexported proteins that may be associated with the virulence phenotype of Corynebacterium pseudotuberculosis strains

Protein Descriptiona

GenBank Accession

Identified in the exoproteome of the strainb:

Orhologs found in other Corynebacteriac:

References


1002

C231

Pathogenic

Non-pathogenic


Phospholipase D (PLD)

ADL09524.1

No

Yes

Yes

No

[54]

Iron siderophore binding protein (FagD)

ADL09528.1

No

Yes

Yes

Yes

[6]

Serine proteinase precursor (CP40)

ADL11339.1

No

Yes

No

No

[57]


Putative iron transport system binding (secreted) protein

ADL10460.1

No

Yes

Yes

No

[12]

Glycerophosphoryl diester phosphodiesterase

ADL11410.1

No

Yes

Yes

No

This work. [72]

Putative surface-anchored membrane protein

ADL20074.1

Yes

Yes

Yes

No

This work.

Putative hydrolase (lysozyme-like)

ADL20788.1

Yes

Yes

Yes

No

This work.

Putative secreted protein

ADL21714.1

Yes

Yes

Yes

No

This work.

Putative sugar-binding secreted protein

ADL09872.1

No

Yes

Yes

No

This work.


The inclusion criteria followed three main requisites: (i) experimental detection of the proteins in the exoproteomes of the pathogenic C. diphtheriae and C. jeikeium; (ii) non-detection of the proteins in the exoproteomes of the non-pathogenic C. glutamicum and C. efficiens; and (iii) in silico detection of ortholog proteins in pathogenic, but not in non-pathogenic, corynebacteria through search of similarity against public protein repositories.

a This protein list is not meant to be all-inclusive. Rather, it wants to give an overview of the exported proteins identified in this study for which it was possible to speculate on a probable involvement in C. pseudotuberculosis virulence after comparative proteomic analyses.

b Proteins identified in this study by TPP/LC-MSE

c Searches of similarity against publicly available protein databases using Blast-p.

Pacheco et al. BMC Microbiology 2011 11:12   doi:10.1186/1471-2180-11-12

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