Open Access Highly Accessed Research article

Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes

Mikihiko Kawai123, Yoshikazu Furuta12, Koji Yahara45, Takeshi Tsuru26, Kenshiro Oshima7, Naofumi Handa12, Noriko Takahashi12, Masaru Yoshida8, Takeshi Azuma8, Masahira Hattori7*, Ikuo Uchiyama3 and Ichizo Kobayashi126*

Author Affiliations

1 Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan

2 Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan

3 National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Aichi, 444-8585, Japan

4 Graduate School of Medicine, Kurume University, Kurume, Fukuoka, 830-0011, Japan

5 Fujitsu Kyushu Systems LTD, Fukuoka, Fukuoka 814-8589, Japan

6 Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Minato-ku, Tokyo, 108-8639, Japan

7 Department of Computational Biology, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba, 277-8561, Japan

8 Department of Gastroenterology, Graduate School of Medicine, Kobe University, Chuou-ku, Kobe, Hyogo, 650-0017, Japan

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BMC Microbiology 2011, 11:104  doi:10.1186/1471-2180-11-104

Published: 16 May 2011

Additional files

Additional file 1:

Phylogenetic tree of H. pylori based on MLST genes

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Additional file 2:

Genes characterizing East Asian strains: domain-based analysis.

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Additional file 3:

Mutations in molybdenum-related genes of H. pylori.

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Additional file 4:

Primers for sequence validation.

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Additional file 5:

Distance values of 692 genes with complete separation of hspEAsia and hpEurope.

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Additional file 6:

Multiple sequence alignments of diverged genes.

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Additional file 7:

Examination of robustness of extraction of diverged genes.

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Additional file 8:

Differences in gene assignment.

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