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Open Access Highly Accessed Research article

Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis

Farahnaz Movahedzadeh*, Paul R Wheeler, Premkumar Dinadayala, Yossef Av-Gay, Tanya Parish, Mamadou Daffé and Neil G Stoker

BMC Microbiology 2010, 10:50  doi:10.1186/1471-2180-10-50

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mycothiol biosynthesis starts from Ins-1-P not Ins

Ralf Stephan   (2010-08-20 12:22)  none email

The authors claim that inositol and thus, Ins-P phosphatase avtivity, is necessary for mycothiol biosynthesis in M. tuberculosis. This is not the case.

In short, mycothiol biosynthesis appears to start from inositol-1-phosphate, not inositol, thus doing away with the claimed need for IMPase in mycothiol biosynthesis because inositol-1-phosphate is readily made from glucose-6-phosphate, catalyzed by Ino1.

Reference:
G. L. Newton, P. Ta, K. P. Bzymek, and R. C. Fahey. Biochemistry of the initial steps of mycothiol biosynthesis. J Biol Chem, 281(45):33910–20, Nov 2006.
PMID 16940050

Regards,
Ralf Stephan
Librarian, currently working on bioinformatics annotation of M.tb.

Competing interests

None.

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