Table 1

Effects of antibiotics on the growth and DON-transforming activity of bacteria from the large (LIC) or small (SIC) intestine.

Antibiotics

Final concen (μg/mL)

LIC-S2

LIC-S3

SIC-S2

SIC-S3





Growth

DON to DOM-1 (%)

Growth

DON to DOM-1 (%)


No antibiotic

0

+++

100.0

N/A

+++

100.0

+++

100.0

Streptomycin

100

+++

49.3

+++

25.6

+++

44.3

+++

5.8

50

+++

100.0

+++

30.8

+++

48.7

+++

11.4

5

+++

100.0

+++

100.0

+++

100.0

+++

100.0

Gentamicin

80

+++

18.1

+++

6.0

++

44.0

+++

7.1

40

+++

23.5

+++

6.5

+++

44.8

+++

7.4

5

+++

100.0

+++

22.5

+++

46.5

+++

6.8

Bacitracin

60

++

16.2

++

0.0

+++

45.0

+++

8.0

30

++

16.1

++

2.5

+++

45.0

+++

8.8

5

+++

15.8

+++

3.9

+++

47.0

+++

11.9

No antibiotic

0

+++

100.0

+++

100.0

+++

100.0

+++

100.0

Penicillin G

100

+

12.1

+++

1.5

++

100.0

+

35.5

50

+

12.7

+++

7.4

++

100.0

+

44.1

5

++

100.0

+++

100.0

+++

100.0

+++

100.0

Virginiamycin

20

+++

100.0

+++

100.0

+++

100.0

+++

100.0

10

+++

100.0

+++

100.0

+++

100.0

+++

100.0

5

+++

100.0

+++

100.0

+++

100.0

+++

100.0

Lincomycin hydrochloride

60

+++

100.0

+++

100.0

+++

31.3

+++

3.6

30

+++

100.0

+++

100.0

+++

100.0

+++

100.0

5

+++

100.0

+++

100.0

+++

47.3

+++

100.0

No antibiotic

0

+++

100.0

+++

100.0

+++

100.0

+++

100.0

Salinomycin

80

+++

16.7

+++

2.0

+++

55.2

+++

8.9

40

+++

18.0

+++

4.0

+++

89.2

+++

80.9

5

+++

16.8

+++

100.0

+++

100.0

+++

100.0

Vancomycin

30

+++

15.9

+++

2.5

++

46.2

+++

9.6

15

+++

15.0

+++

2.2

++

44.9

+++

10.5

5

+++

38.5

+++

13.2

++

46.8

+++

9.7

Carbadox

50

+++

16.4

++

3.5

++

27.7

+++

3.9

25

+++

100.0

+++

45.2

+++

100.0

+++

52.7

5

+++

100.0

+++

78.7

+++

100.0

+++

100.0

Tylosin

80

+++

100.0

+++

100.0

+++

100.0

+++

79.4

40

+++

100.0

+++

100.0

+++

100.0

+++

92.2

5

+++

100.0

+++

94.5

+++

100.0

+++

100.0


Note: LIC-S2 and SIC-S2 mean inoculum from the first sub-culture of the large intestinal digesta or small intestinal digesta, respectively.

+ means slight growth; ++ moderate growth; +++ vigorous growth

Yu et al. BMC Microbiology 2010 10:182   doi:10.1186/1471-2180-10-182

Open Data