Open Access Research article

Revealing fosfomycin primary effect on Staphylococcus aureus transcriptome: modulation of cell envelope biosynthesis and phosphoenolpyruvate induced starvation

Marko Petek1*, Špela Baebler1, Drago Kuzman2, Ana Rotter1, Zdravko Podlesek3, Kristina Gruden1, Maja Ravnikar1 and Uroš Urleb2

Author Affiliations

1 Department of Biotechnology and Systems Biology, National Institute of Biology, Večna pot 111, Ljubljana, SI-1000, Slovenia

2 Novartis BPO Mengeš, Lek Pharmaceuticals d.d., Kolodvorska 27, Mengeš, SI-1234, Slovenia

3 Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, Ljubljana, SI-1000, Slovenia

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BMC Microbiology 2010, 10:159  doi:10.1186/1471-2180-10-159

Published: 1 June 2010

Additional files

Additional file 1:

Summary table for differentially expressed genes. Excel spreadsheet file summarizing the transcriptional data from our study and publicly available transcriptional profiling results from SAMMD.

Format: XLS Size: 3MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Pathway Studio metabolic network. File containing the representation of S. aureus metabolic network (gpc format). The file can be viewed by Pathway Studio software webcite.

Format: GPC Size: 18.6MB Download file

Open Data

Additional file 3:

Gene sets used for GSEA. Excel spreadsheet file containing gene sets generated from TIGRFAM ontology that were used to run GSEA.

Format: XLS Size: 90KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data