Table 1

Gene Ontology: biological process – up-regulated genes in tolerant hearts compared to syngeneic controls
List Name
 Total probes
 Expected matches
 Actual matches
 Fold Enrichment
 Binomial p-values
response to biotic stimulus
 1353
 22.64
 61
 2.69
 1.16E-11
defense response
 1275
 21.33
 53
 2.48
 3.86E-09
immune response
 1166
 19.51
 50
 2.56
 3.87E-09
response to virus
 108
 1.81
 12
 6.64
 3.04E-07
response to pest, pathogen or parasite
 767
 12.83
 33
 2.57
 1.41E-06
response to other organism
 782
 13.08
 33
 2.52
 2.13E-06
response to stimulus
 3134
 52.44
 87
 1.66
 6.47E-06
JAK-STAT cascade
 66
 1.1
 8
 7.24
 1.49E-05
protein kinase cascade
 610
 10.21
 26
 2.55
 2.02E-05
response to pathogenic bacteria
 24
 0.4
 5
 12.45
 4.27E-05
regulation of DNA binding
 15
 0.25
 4
 15.94
 9.23E-05
I-kappaB kinase/NF-kappaB cascade
 223
 3.73
 13
 3.48
 1.18E-04
nuclear transport
 254
 4.25
 14
 3.29
 1.19E-04
nucleocytoplasmic transport
 276
 4.62
 14
 3.03
 2.79E-04
response to pathogen
 35
 0.59
 5
 8.54
 2.80E-04
maintenance of localization
 38
 0.64
 5
 7.86
 4.15E-04
response to bacteria
 59
 0.99
 6
 6.08
 4.63E-04
regulation of binding
 23
 0.38
 4
 10.39
 5.38E-04
response to stress
 1778
 29.75
 49
 1.65
 6.71E-04
T cell receptor signaling pathway
 14
 0.23
 3
 12.81
 1.48E-03
immune cell mediated cytotoxicity
 15
 0.25
 3
 11.95
 1.83E-03
negative regulation of protein import into nucleus
 15
 0.25
 3
 11.95
 1.83E-03
negative regulation of transcription factor import into nucleus
 15
 0.25
 3
 11.95
 1.83E-03
cytoplasmic sequestering of transcription factor
 15
 0.25
 3
 11.95
 1.83E-03
cytoplasmic sequestering of protein
 15
 0.25
 3
 11.95
 1.83E-03
negative regulation of nucleocytoplasmic transport
 16
 0.27
 3
 11.21
 2.23E-03
negative regulation of protein transport
 16
 0.27
 3
 11.21
 2.23E-03
inflammatory response
 311
 5.2
 13
 2.5
 2.57E-03
cholesterol metabolism
 140
 2.34
 8
 3.42
 2.61E-03
tyrosine phosphorylation of STAT protein
 17
 0.28
 3
 10.55
 2.67E-03
regulation of NF-kappaB import into nucleus
 17
 0.28
 3
 10.55
 2.67E-03
NF-kappaB import into nucleus
 17
 0.28
 3
 10.55
 2.67E-03
antigen receptor-mediated signaling pathway
 18
 0.3
 3
 9.96
 3.17E-03
nuclear export
 115
 1.92
 7
 3.64
 3.34E-03
cell killing
 19
 0.32
 3
 9.44
 3.71E-03
sterol metabolism
 149
 2.49
 8
 3.21
 3.82E-03
detection of stimulus
 63
 1.05
 5
 4.74
 4.12E-03
positive regulation of apoptosis
 368
 6.16
 14
 2.27
 4.18E-03
positive regulation of programmed cell death
 368
 6.16
 14
 2.27
 4.18E-03
detection of external stimulus
 41
 0.69
 4
 5.83
 4.85E-03
detection of abiotic stimulus
 41
 0.69
 4
 5.83
 4.85E-03
DNA metabolism
 1205
 20.16
 33
 1.64
 4.94E-03
viral genome replication
 42
 0.7
 4
 5.69
 5.29E-03
RNA export from nucleus
 97
 1.62
 6
 3.7
 5.94E-03
nucleic acid transport
 97
 1.62
 6
 3.7
 5.94E-03
RNA transport
 97
 1.62
 6
 3.7
 5.94E-03
establishment of RNA localization
 97
 1.62
 6
 3.7
 5.94E-03
caspase activation
 44
 0.74
 4
 5.43
 6.25E-03
response to drug
 44
 0.74
 4
 5.43
 6.25E-03
positive regulation of caspase activity
 44
 0.74
 4
 5.43
 6.25E-03
lipid transport
 131
 2.19
 7
 3.19
 6.78E-03
RNA localization
 101
 1.69
 6
 3.55
 7.20E-03

Doki et al. BMC Immunology 2008 9:5   doi:10.1186/1471-2172-9-5