Table 3

Interferon and interferon-inducible genes in human B cells were minimally and inconsistently modulated by TLR7, 8, or 9 agonists from 3 different donors (maximum fold-change through a 2, 8, 24 hour time course).
Gene
 Alias
 3M-006
 3M-002
 852A
 3M-003
 CpG 2006


D1
 D2
 D3
 D1
 D2
 D3
 D1
 D2
 D3
 D1
 D2
 D3
 D1
 D2
 D3
GAPDH
 GAPDH
 1.0*
 1.0*
 1.0*
 1.0*
 1.0*
 1.0*
 1.0*
 1.0*
 1.0*
 1.0*
 1.0*
 1.0*
 1.0*
 1.0*
 1.0*
IFNa-2
 IFNa-2
 2.6
 1.7
 1.5
 3.5
 1.8
 1.4
 3.0
 -1.3
 1.2
 -2.2
 -1.5
 -1.2
 4.0
 -1.7
 -1.2
ISG15
 ISG15
 1.6
 1.3
 1.2
 1.9
 1.1
 1.5
 1.2
 1.5
 1.8
 3.0
 -2.7
 2.3
 -1.5
 -2.2
 -1.5
MX1
 MX1
 1.3
 -1.2
 1.3
 1.7
 -1.5
 1.1
 1.5
 -2.3
 -1.6
 6.8
 -3.3
 -4.2
 -3.9
 -3.4
 -4.3
TLR7
 TLR7
 1.5
 -1.2
 1.6
 1.2
 -1.3
 1.3
 -2.8
 -2.7
 -1.6
 -2.9
 -2.1
 -4.3
 -3.5
 -6.7
 -4.5
TLR9
 TLR9
 -1.3
 -1.2
 -1.1
 1.0
 -1.3
 -1.1
 -1.9
 -1.5
 -1.4
 -3.1
 -3.9
 -2.3
 -3.2
 -3.0
 -1.7

The data represented in Table 3 and Table 2 are from the same experiment, but were separated into 2 different tables for illustration purposes.

(a) normal text = subjectively assigned nominal to low fold change (-3.4 to 3.4).

(b) bold text, negative = subjectively assigned moderate fold suppression (-23.0 to -3.5).

(c) bold text, positive = subjectively assigned moderate to high fold increase (3.5 to 86.0).

(d) text with * = GAPDH, house keeping gene as a reference.

Hanten et al. BMC Immunology 2008 9:39   doi:10.1186/1471-2172-9-39