|
Relationship between baseline variables and levels of total IgE before treatment. |
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| Geometric mean total IgE at baseline |
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| Variable |
Model 1 |
Model 2 |
Model 3 |
Model 4 |
|||||
| Fold difference (95% CI) |
p value |
Fold difference (95% CI) |
p value |
Fold difference (95% CI) |
p value |
Fold difference (95% CI) |
p value |
||
|
|
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| Age (per year) |
1.01 (0.94–1.10) |
0.74 |
1.01 (0.94–1.09) |
0.78 |
1.02 (0.94–1.10) |
0.70 |
1.05 (0.97–1.12) |
0.23 |
|
| Sex (females relative to males) |
0.83 (0.64–1.07) |
0.15 |
0.84 (0.65–1.09) |
0.20 |
0.85 (0.66–1.10) |
0.22 |
0.86 (0.68–1.10) |
0.24 |
|
| Body Mass Index (per kg/m2) |
1.01 (0.94–1.08) |
0.81 |
1.01 (0.95–1.08) |
0.73 |
1.01 (0.95–1.08) |
0.68 |
1.00 (0.94–1.06) |
0.98 |
|
| Socioeconomic level (per unit score) |
1.10 (0.95–1.27) |
0.18 |
1.09 (0.94–1.26) |
0.25 |
1.11 (0.96–1.28) |
0.17 |
1.06 (0.93–1.21) |
0.40 |
|
| Crowding (per person/sleeping room) |
0.98 (0.87–1.10) |
0.74 |
0.98 (0.87–1.10) |
0.74 |
0.97 (0.87–1.09) |
0.66 |
1.00 (0.90–1.11) |
0.99 |
|
| Treated group (relative to untreated) |
0.95 (0.73–1.24) |
0.71 |
0.95 (0.73–1.23) |
0.69 |
0.96 (0.74–1.25) |
0.79 |
0.96 (0.75–1.23) |
0.75 |
|
| Geohelminth prevalence at t = 0 (present versus absent) |
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| Any |
2.10 (1.60–2.75) |
<0.001 |
1.55 (1.19–2.01) |
0.001 |
|||||
| A. lumbricoides |
1.38 (0.99–1.91) |
0.06 |
|||||||
| T. trichiura |
1.79 (1.31–2.46) |
<0.001 |
|||||||
| Hookworm |
1.60 (0.99–2.60) |
0.06 |
1.55 (0.95–2.52) |
0.08 |
|||||
| S. stercoralis |
0.77 (0.26–2.23) |
0.62 |
0.71 (0.24–2.05) |
0.52 |
|||||
| Geohelminth intensity (epg) at t = 0 (relative to no infection) |
|||||||||
| A. lumbricoidesa |
1–8000 |
1.55 (1.05–2.30) |
0.03 |
||||||
| >8000 |
1.33 (0.85–2.08) |
0.21 |
|||||||
| T. trichiurab |
1–500 |
1.32 (0.90–1.96) |
0.16 |
||||||
| >500 |
2.23 (1.44–3.43) |
<0.001 |
|||||||
| Anti-A. lumbricoides antibodies at t = 0 |
|||||||||
| (relative to lower tertile) IgGc |
|||||||||
| middle tertile |
1.64 (1.21–2.23) |
0.001 |
|||||||
| upper tertile |
3.51 (2.55–4.82) |
<0.001 |
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|
Statistical significance, after Bonferroni corrections, is inferred by: Model 1 (P < 0.05), Model 2 (P < 0.01), Model 3 (P < 0.008), and Model 4 (P < 0.02). Statistically significant P values are shown in bold for each model. P values for trend: a0.08, b, c<0.001. | |||||||||
Cooper et al. BMC Immunology 2008 9:33 doi:10.1186/1471-2172-9-33 |
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