Table 5

Top 10 functional annotations for two merged networks downregulated in response to LPS (based on p value).

Category

Term

# of genes

p-value

SP_PIR_KEYWORDS

aminoacyl-tRNA synthatase

6

1.7E-4

SP_PIR_KEYWORDS

protein biosynthesis

8

5.2E-4

GOTERM_BP_ALL

sterol metabolism

7

6.0E-4

GOTERM_BP_ALL

cellular physiological process

57

7.0E-4

GOTERM_BP_ALL

biosynthesis

21

1.0E-3

GOTERM_MF_ALL

aminoacyl-tRNA ligase activity

6

1.3E-3

GOTERM_MF_ALL

ligase activity, carbon-oxygen bonds

6

1.3E-3

GOTERM_BP_ALL

amino acid activation

6

1.6E-3

GOTERM_BP_ALL

tRNA aminoacylation for protein translation

6

1.6E-3

GOTERM_BP_ALL

tRNA amioacylation

6

1.6E-3

The analysis is based on the default parameters in D.A.V.I.D. and uses Benjamini-Hochberg correction for multiple testing.

Wong et al. BMC Immunology 2008 9:24   doi:10.1186/1471-2172-9-24