|
ATRA, 9-cis RA and 13-cis RA significantly increase the expression of CD38 and CD69 on T cells in anti-CD3-stimulated PBMC cultures in a dose-dependentfashion. |
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| CD38 MCN |
Fold vs Control ± SE (n = 3) |
|||
|
|
||||
| Dose (nM) |
||||
|
|
||||
| 1 |
10 |
100 |
1000 |
|
|
|
||||
| Retinoid |
||||
| ATRA |
1.49 ± 0.07 |
1.60 ± 0.05 |
1.63 ± 0.07 |
1.67 ± 0.05 |
| 9-cis-RA |
1.11 ± 0.02 |
1.43 ± 0.02 |
1.77 ± 0.08 |
1.93 ± 0.02 |
| 13-cis-RA |
1.28 ± 0.06 |
1.50 ± 0.06 |
1.68 ± 0.10 |
1.71 ± 0.08 |
| 4-HPR |
1.11 ± 0.02 |
1.15 ± 0.02 |
1.20 ± 0.02 |
1.66 ± 0.19 |
| 2-way ANOVA |
||||
| Dose |
p = 0.0001 |
|||
| Retinoid |
p < 0.0001 |
|||
| Tukey Kramer |
||||
| Dose |
p < 0.01 |
1 nM vs 10 nM |
||
| 1 nM vs 100 nM |
||||
| 1 nM vs 1000 nM |
||||
| Retinoid |
p < 0.01 |
4-HPR vs ATRA |
||
| 4-HPR vs 9-cis RA |
||||
| 4-HPR vs 13-cis RA |
||||
|
|
||||
| CD69 MCN |
Fold vs Control ± SE (n = 3) |
|||
|
|
||||
| Dose (nM) |
||||
|
|
||||
| 1 |
10 |
100 |
1000 |
|
|
|
||||
| Retinoid |
||||
| ATRA |
1.29 ± 11.0 |
1.27 ± 10.5 |
1.40 ± 0.14 |
1.46 ± 0.15 |
| 9-cis-RA |
1.07 ± 3.4 |
1.27 ± 8.2 |
1.59 ± 0.16 |
1.64 ± 0.15 |
| 13-cis-RA |
0.99 ± 4.0 |
1.12 ± 3.4 |
1.24 ± 0.08 |
1.33 ± 0.11 |
| 4-HPR |
0.85 ± 6.2 |
0.86 ± 3.3 |
0.94 ± 0.04 |
1.08 ± 0.04 |
| 2-way ANOVA |
||||
| Dose |
p = 0.0001 |
|||
| Retinoid |
p < 0.0001 |
|||
| Tukey Kramer |
||||
| Dose |
p < 0.01 |
1 nM vs 100 nM |
||
| 1 nM vs 1000 nM |
||||
| Retinoid |
p < 0.01 |
4-HPR vs ATRA |
||
| 4-HPR vs 9-cis-RA |
||||
| 4-HPR vs 13-cis-RA |
||||
Dawson et al. BMC Immunology 2008 9:16 doi:10.1186/1471-2172-9-16 |
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