Figure 2.

The effects of various clinically-utilized retinoid compounds on Th1-associated cytokine production by anti-CD3e-activated PBMCs. Supernatants of anti-CD3e-activated PBMCs treated with EtOH or 10^-9 to 10^-6 M ATRA (○), 9-cis-RA (□), 13-cis-RA (●), or 4-HPR (■) for 48 h were examined for IFN-γ or IL-12 protein levels by ELISA analysis. The values shown represent the average fold change obtained from 4 donors.