BMC Immunology

official impact factor 3.00

Open Access Highly Access Research article

Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists

Woubalem Birmachu1*, Raymond M Gleason1, Barbara J Bulbulian1, Christie L Riter1, John P Vasilakos1, Kenneth E Lipson1 and Yuri Nikolsky2

Author Affiliations

1 Pharmacology, 3M Pharmaceuticals, St Paul, Minnesota, USA

2 GeneGo Inc, St. Joseph, Michigan, USA

For all author emails, please log on.

BMC Immunology 2007, 8:26 doi:10.1186/1471-2172-8-26

Published: 12 October 2007

Additional files

Additional file 1:

Genes altered in expression 4 hr post-stimulation of pDC with 3M-852A and 3M-011. This file summarizes the log2 fold change in expression for 680 genes altered in expression upon treatment of pDC with 3M-852A and 3M-011, 4 hr post stimulation. Fold change in expression was calculated with respect to vehicle-treated samples from the same donor. Genes were selected if the probes sets had signal detection p-value less than 0.01 and an expression change p-value less than 0.005 across replicates for each TLR agonist.

Format: DOC Size: 1.3MB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 2:

Legend describing symbols used in networks. Legend provides a key to the symbols used in the MetaCore networks.

Format: PNG Size: 106KB Download file

Open Data