Additional file 1.

Lateral transfer of JEC21 from an infected to an uninfected human primary macrophage. The infected (donor) cell is highlighted in the first frame. The donor cell moves underneath the recipient cell and, at 1:25, the recipient macrophage contacts the cryptococcal phagosome. About 160 min after the onset of filming, membrane fusion starts to occur at the contact point of the two cells and initiates lateral transfer of the yeast from the donor cell to the recipient cell. The whole process takes only seven minutes. Upon completion, the cryptococcal cell is entirely in the recipient macrophage and the donor macrophage moves away.

Format: MOV Size: 7.8MB Download file

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Ma et al. BMC Immunology 2007 8:15   doi:10.1186/1471-2172-8-15