Figure 6.

Cell movement in the presence and absence of metallothionein and SDF-1α. Images at 3 minute intervals (over a 75 minute time period) are presented for untreated cells (A), cells treated with a uniform concentration of MT(0.5 μM) (B), or SDF-1α (100 ng/ml) (C), or cells moving under agar in a chemotactic gradient of MT (20 μM) (D) or SDF-1α (200 ng/ml) (E). Each panel has the same number of images and represents the same total time interval. The line at the bottom of panels D and E represents the direction of the chemoattractant gradient from high (wide) to low (narrow). Only cells that have exited the cell well and are clearly visible under the agarose were analyzed.