Figure 5.

Amino acid alignment of deer mouse (Pema), house mouse (Mus), rat (Rattus) and human (Homo) IL-21. Sequences were aligned as described in Figure 1. The deer mouse fragment represents 84% of the polypeptide and includes the first three and part of the fourth helices (A-D, underlined). Conserved cysteines (*) and an aspartic acid (+) involved in receptor binding are also present in deer mouse IL-21.