|
|
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| Immunizationa |
Challengeb |
Number of Mice with Anaphylaxis |
||
|
|
||||
| Temperature Decrease ≥ 1 °C |
Death (all mice) |
Death (in mice with anaphylaxis) |
||
|
|
||||
| G7 peptides |
G7 peptides |
14/14 (100%) * |
12/14 (86%)** |
12/14 (86%)*** |
| PD peptides |
PD peptides |
3/7 (43%) † |
1/7 (14%) |
1/3 (33%) |
| HEL/OVA |
HEL/OVA |
5/12 (42%) ‡ |
4/12 (33%) ‡‡ |
4/5 (80%) ‡‡‡ |
| Saline |
Saline |
0/13 (0%) |
0/13 (0%) |
- |
| None (no injection) |
None (no injection) |
0/9 (0%) |
0/9 (0%) |
- |
| No injection |
G7 peptides |
0/9 (0%) |
0/9 (0%) |
- |
|
|
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| Passive Systemic IgE-induced Anaphylaxis |
||||
|
|
||||
| IgE anti-DNP |
DNP-HSA |
10/10 (100%)# |
0/10 (0%) |
0/10 (0%) |
|
a Immunizations in IFA b Challenge in 0.9% NaCl (saline) * P = 0.0058 vs. PD challenged, P = 0.0012 vs. HEL/OVA challenged, P < 0.0001 vs. G7 challenged non-immunized mice, saline challenged or "none" groups; † P = 0.031 vs saline challenged; ‡ P < 0.05 vs G7 challenged non-immunized mice, saline challenged or "none" groups; # P = 0.0147 vs PD challenged, P = 0.0053 vs HEL/OVA, P < 0.0001 vs G7 challenged non-immunized mice, saline challenged or "none" groups.; ** P = 0.0138 vs. HEL/OVA challenged, P < 0.0001 vs DNP-HSA challenged; ‡‡ P = 0.048 vs saline challenged; *** P < 0.0001 vs DNP-HSA challenged; ‡‡‡ P = 0.0037 vs DNP-HSA challenged; all other comparisons are P > 0.05 (Fisher exact test). | ||||
Pedotti et al. BMC Immunology 2003 4:2 doi:10.1186/1471-2172-4-2 |
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