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This article is part of the supplement: Proceedings of Delivery Systems and Current Strategies to Drug Design

Open Access Proceedings

Immunogenicity and cross-reactivity against Mycobacterium tuberculosis of proteoliposomes derived from Mycobacterium bovis BCG

Fátima Reyes1, Yanely Tirado1, Alina Puig1, Reinier Borrero1, Giselle Reyes1, Sonsire Fernández1, José Luis Pérez1, Ramlah Kadir2, Caridad Zayas1, Mohd Nor Norazmi23*, María E Sarmiento1 and Armando Acosta1

Author affiliations

1 Finlay Institute. Ave. 27 No. 19805, Havana, Cuba. AP. 16017, CP11600

2 School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia

3 Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 16150 Kubang Kerian, Malaysia

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Citation and License

BMC Immunology 2013, 14(Suppl 1):S7  doi:10.1186/1471-2172-14-S1-S7

Published: 25 February 2013

Abstract

The only currently available vaccine against tuberculosis (TB) is Mycobacterium bovis Bacille Calmette-Guerin (BCG), which has inconsistent efficacy to protect against the disease in adults. M. tuberculosis (MTB) cell wall components have been implicated in the pathogenicity of TB and therefore have been a prime target for the identification and characterization of cell wall proteins with potential application in vaccine development. In this regard, proteoliposomes (PLs) derived from mycobacteria containing lipids and cell wall proteins could be potential vaccine candidates against TB. In the present study PLs derived from BCG were prepared. These homogeneous population of spherical microparticles was then immunized into Balb/c mice. Sera of immunized animals showed high IgG response and strong cross-reactivity against different MTB antigens.These results showed that BCG PLs could be potential vaccine candidates against TB.