Open Access Highly Accessed Research article

MicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS)

Margareta Jernås1*, Clas Malmeström2, Markus Axelsson2, Intawat Nookaew5, Hans Wadenvik3, Jan Lycke2 and Bob Olsson4

Author Affiliations

1 Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

2 Department of Neurology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

3 Department of Internal Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Vita Stråket 12, SE-413 45, Gothenburg, Sweden

4 Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

5 Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

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BMC Immunology 2013, 14:32  doi:10.1186/1471-2172-14-32

Published: 29 July 2013

Additional files

Additional file 1: Table S1:

Patient characteristics in the microRNA analysis. Table S2. Significantly regulated microRNAs in T-cells between MS patients and controls. Table S3. Differentially expressed mRNAs in T-cells between MS patients and controls. Figure S1. The identified target genes of the differentially expressed microRNA were cross referenced against the differentially expressed mRNAs between MS patients and controls resulting in 920 overlapping genes.

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