Neutrophil depletion during pulmonary infection with C. neoformans strain H99γ results in significant production of neutrophil chemoattractant cytokines, but little change in Th17-type cytokine production in the lungs. BALB/c mice were given an intranasal inoculation with C. neoformans strain H99γ. Mice were treated with isotype control antibody (white bars) or with anti-1A8 antibody (gray bars). Lung homogenates were prepared from lungs excised on day 7 post-inoculation and assayed for IL-6, G-CSF, CXCL1, TGF-β, IL-21, and IL-23 cytokine production. Data are cumulative of three experiments using 5 mice each per group. Asterisks (*) indicate where significant differences (P < 0.05) were observed.
Wozniak et al. BMC Immunology 2012 13:65 doi:10.1186/1471-2172-13-65