Effect of administration of plasmid DNA on the alterations of MAP, HR and body temperature triggered by LPS in rats. Animals were injected with LPS and plasmid DNA at doses of 5, 10 or 20 μg. Mean arterial blood pressure (ΔMAP) (A, B and C), variability of heart rate (ΔVHR) (D, E and F) and body temperature (G, H and I) were monitored continuously. Results are expressed as mean ± SD of at least two independent experiments. *, P < 0.05 versus control group injected only with physiologic saline. #, P < 0.05 versus group injected with LPS only.
Malardo et al. BMC Immunology 2012 13:59 doi:10.1186/1471-2172-13-59