Role of gamma-delta T cells in host response against Staphylococcus aureus-induced pneumonia
- Equal contributors
1 Department of Clinical Microbiology and Immunology, Faculty of Medical Laboratory Science, Third Military Medical University and National Engineering Technological Research Center of Immunological Biologicals, Chongqing 400038, China
2 Department of Pharmacology, College of Pharmacy, The Third Military Medical University, Chongqing, China
3 College of Life Sciences, Nankai University, Tianjin, China
BMC Immunology 2012, 13:38 doi:10.1186/1471-2172-13-38Published: 9 July 2012
Staphylococcus aureus is the major cause of hospital-acquired and community-acquired pneumonia. Host defense to S.aureus infection is largely mediated by the innate immune system. γδ T cells play an important role in innate immunity to many infectious diseases. However, less is known about the role of these cells during S.aureus-induced pneumonia. In this study, we examined the response and the role of γδ T cells to pulmonary S.aureus infection.
Mice infected with S. aureus intranasally showed rapid γδ T cells accumulation in the lung. Deficiency of γδ T cells led to attenuated bacterial clearance and less tissue damage in lung compared with WT mice. Moreover, TCR-δ−/− mice exhibited impaired neutrophil recruitment and reduced cytokine production at the site of infection. The γδ T cells in response to pulmonary S. aureus infection mainly secreted IL-17 and γδ T cells deficiency reduced IL-17 production, which might regulate the production of neutrophil-inducing cytokine/chemokine in the S. aureus-infected lungs.
Accumulation of γδ T cells in the lungs to S. aureus infection is beneficial for bacteria clearance and also contributes to the tissue damage. These cells were the primary source of IL-17, which might influence the recruitment of neutrophils at the early stage of infection.