Additional file 6.

Figure S2. A schematic presentation of signaling pathways and induced gene profiles via differential stimulation of T cells. This figure highlights the findings of this study indicating that TCR/CD3-induced Calcium signaling is necessary for efficient T helper 1 development, whereas absence of calcium signaling and sufficient activation of NFκB/AP1 lead to T helper 2 development (as indicated by green-red intensity plots). A selected list of genes is listed derived from the IL-2 and CCL1 gene profiles shown in Figure 7.

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Smeets et al. BMC Immunology 2012 13:12   doi:10.1186/1471-2172-13-12