Table 1 |
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|
Hemodynamic and microvascular parameters in cremaster muscle venules during trauma induced inflammation and additional fMLP stimulation |
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|
Mice |
Venules |
Diameter |
Centerline Velocity |
Wall shear rate |
Systemic leukocyte counts |
|
|
(N) |
(n) |
(μm) |
(μm/s) |
(s-1) |
(cells/μl) |
|
|
|
||||||
|
Wild type |
10 |
13 |
33 ± 1 |
2700 ± 200 |
2000 ± 100 |
6600 ± 600 |
|
RAGE-/- |
6 |
10 |
33 ± 2 |
2700 ± 200 |
2100 ± 100 |
6800 ± 900 |
|
Icam1-/- |
4 |
4 |
30 ± 2 |
2400 ± 300 |
2000 ± 300 |
6400 ± 300 |
|
Wild type+ anti-Mac-1 |
6 |
19 |
30 ± 1 |
2500 ± 100 |
2100 ± 100 |
4800 ± 200 |
|
RAGE-/-+ anti-Mac-1 |
4 |
14 |
29 ± 2 |
2500 ± 100 |
2100 ± 150 |
6700 ± 600 |
|
Wild type+ isotype AB |
3 |
9 |
33 ± 2 |
2300 ± 100 |
1800 ± 100 |
6300 ± 700 |
|
Wild type+ anti-LFA-1 |
5 |
16 |
27 ± 1 |
2400 ± 100 |
2200 ± 100 |
6900 ± 700 |
|
RAGE-/-+ anti-LFA-1 |
6 |
20 |
30 ± 1 |
2400 ± 100 |
2200 ± 100 |
7900 ± 700 |
|
Wild type+ isotype AB |
3 |
9 |
29 ± 2 |
2400 ± 100 |
2200 ± 200 |
5300 ± 400 |
|
n.s. |
n.s. |
n.s. |
n.s. |
|||
|
|
||||||
|
Vessel diameter, centerline velocity, wall shear rate and systemic leukocyte counts are presented as mean ± SEM of the investigated venules during trauma-induced inflammation with additional local fMLP superfusion. N.s. = non significant. |
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|
Frommhold et al. BMC Immunology 2011 12:56 doi:10.1186/1471-2172-12-56 |
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