Liver infiltration of IL17+ and Foxp3+ T cells. Foxp3 (→) was distinctly expressed in the nuclei of lymphocytes (D: NC, E: CLF, F: ACLF) (×400) while IL-17 (→) showed granular cytoplastic staining (A: NC, B: CLF, C: ACLF) (×400). A large number of lymphocytes infiltrated into the livers of the CLF and ACLF patients. IL17+ and Foxp3+ T cells were mainly located in the portal area of the liver and could still be found in the lobe, especially in the necrotic area (C). NC, normal control; CLF, HBV-related chronic liver failure; ACLF, HBV-related acute on chronic liver failure.
Niu et al. BMC Immunology 2011 12:47 doi:10.1186/1471-2172-12-47