MΦ depletion by Cl2MDP-liposomes inhibits tumor growth in the Hepa1-6 induced tumor model. (A) Experimental outline for MΦ depletion by administration of Cl2MDP-liposomes in s.c. tumor-bearing mice. Saline and PBS-liposomes were used as the controls. (B) Size of the s.c.-transplanted tumors (n = 15). Data are representative of three independent experiments. (C) Experimental outline for administration of Cl2MDP-liposomes in orthotopic tumor-bearing mice. (D) Weights of orthotopically transplanted tumors (n = 12). The bars represent the mean ± SD; *p < 0.05, ***p < 0.001 (unpaired Student's t-test).
Wang et al. BMC Immunology 2011 12:43 doi:10.1186/1471-2172-12-43