Histamine-induces enhanced hypothermia in 129S5 mice. a) Rectal temperature 0-60 minutes and (b). Maximal rectal temperature change at 30 minutes following i.v. injection of histamine (5 mg/200 μl saline). Data presented as means ± SEM (n = 6-8) and is representative of two separate experiments. Data were analyzed by one-way analysis of variance (ANOVA) and a post-hoc comparison test (Tukey-Kramer). (a) Single and double asterisks indicate a P value < 0.05 and < 0.01 compared with BALB/c + histamine. (b) Single asterisk indicate a P value less than < 0.05.
Arumugam et al. BMC Immunology 2011 12:14 doi:10.1186/1471-2172-12-14