Table 4

Epitope binding predictions for DRB1 alleles that are common in TB high-burden countries

DRB1 Allele1

Median total (conserved) epitopes

N2

Association with tuberculosis (reference)

Tuberculosis-endemic populations where allele is highly prevalent4


0101

122 (76)

9

NK3

Russian Chuvash, Aleuts and Tuva, Indian Islamic populations

0102

46 (30)

3

NK

Ethiopia (Amhara)

0301

11 (4)

6

Protective [29]

Brazil, northern China, Ethiopia (Oromo), northern and eastern India, northwestern Russia, Thailand (Bangkok), South Africa (Venda)

0302

0 (0)

1

NK

South Africa (Venda)

0401

29 (15)

8

NK

Chinese Inner Mongolian Evenki, Russian Chukchi, Eskimo, Koryak, Buryat, and Negidal populations

0403

11 (4)

1

NK

Russian Buryat and Nganasan populations

0404

16 (8)

6

NK

Brazil Kaingang indigenous population

0405

20 (11)

6

NK

Philippines

0411

7 (3)

1

NK

Brazil indigenous populations

0701

16 (9)

8

Protective [29]

Brazil, Northern and Eastern China, Democratic Republic of the Congo, Ethiopia, Indonesia (Java), Russian Bearian Island Aleuts, Russia Chuvash, Russia (Siberia), Thailand (Bangkok), Vietnam (Hanoi)

0801

9 (7)

2

Susceptible [29]

Russia (Kets)

0802

7 (3)

4

Susceptible [29]

Brazil indigenous populations, Russian Eskimos

0803

2 (1)

1

Susceptible [52]

China (Yunnan Province)

0804

7 (5)

2

NK

Brazil East Amazon indigenous populations

0807

2 (2)

1

NK

Brazil Guarani Kaiowa and Ticuna indigenous populations

0901

23 (10)

5

NK

Brazil Southeast Caucasian population, China, Russia (Siberia), Thailand, Vietnam (Hanoi)

1001

138 (77)

1

NK

Northern and eastern India, Russian Buryat population

1101

13 (5)

7

Susceptible [53]; Protective [29]

Northeast Brazil, Northern and central China, Democratic Republic of the Congo, northern India, Indonesia (Molucca and Nusa Tenggara), Russian Evenks, Nganasan, and Tuva populations, Zimbabwe (Harare)

1201

13 (7)

2

NK

China (Southern and Harbin), northeast India, Russia (Siberia)

1202

8 (2)

1

NK

Southern and central China, Hong Kong and Singapore, Indonesia, Philippines, Thailand, Vietnam (Hanoi)

1301

8 (5)

4

Protective [29]

Brazil, China (Xinjiang), Democratic Republic of the Congo, India (Andhra Pradesh), Russia (Kets, Khanty-Mansi), South Africa (Venda), Zimbabwe (Harare)

1302

14 (8)

6

Susceptible [53]; Protective [29,53]

Brazil Southeast Mulattos, Democratic Republic of the Congo, Ethiopia

1303

9 (5)

1

NK

Democratic Republic of the Congo, Northeast India

1401

5 (3)

1

Susceptible [29]

Southern China, Northern India, Philippines, Russian Nivkhi and Evenki, Udege, and Ulchi, Vietnamese Muong

1402

19 (8)

1

NK

Brazil Xavantes, Guarani, and Terena; Russian Chukchi, Eskimos, Koryaks, Nivkhi, and Udege

1403

2 (0)

1

NK

Chinese Drung, Russian Evenki and Kets

1404

3 (2)

1

NK

China Naxi and Lisu, India (Delhi)

1405

10 (3)

1

NK

Chinese Wa Population

1413

38 (19)

1

NK

Brazil Guarani M bya population

1501

15 (9)

8

Susceptible [29,54,55]

China, Hong Kong and Singapore, India, Indonesia, Russia (Siberia), Northeast Thailand

1502

12 (5)

2

Susceptible [29]

Chinese Jino population, India, Indonesia, Philippines, Thailand, Vietnam

1503

15 (8)

1

NK

Zimbabwe (Harare)

1504

6 (2)

1

NK

Chinese Nu and Va populations

1602

17 (6)

1

NK

Brazil Xavantes, Guarani, Kaingang, Terena, and Ticuna populations, Chinese Maonan and Miao populations, Northern Thailand, Vietnamse Muong


1Alleles of particular concern (median of four or fewer conserved vaccine epitopes) are highlighted with italics.

2N = number of programs able to predict epitope binding to that allele

3NK = None known

4Of the study populations included in the Allele*Frequencies in Worldwide Populations database [25]

McNamara et al. BMC Immunology 2010 11:18   doi:10.1186/1471-2172-11-18

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