Improving TWINSCAN's prediction on exons. ROC curves by applying the log odds ratio on TWINSCAN's exons. The x-axis is the false prediction rate (FP) of the exon by the log odds score and the y-axis is the true prediction rate (TP) of the exon by the log odds score. The upper graph is the result from human-mouse alignments of TWINSCAN's exons. The lower graph is the result from human-dog alignments of TWINSCAN's exons. The plot shows that by using the log odds score to refine TWINSCAN, we could largely reduce the number of false predictions, e.g., by 32% while keeping over 99% of true positives. The plot also shows that the improvement on TWINSCAN is not affected by the type of alignments used since the two curves are almost identical.
Wu BMC Genomics 2008 9(Suppl 2):S13 doi:10.1186/1471-2164-9-S2-S13