Abundance of intrinsic disorder in disease-associated proteins. Percentages of disease associated proteins with ≥ 30 to ≥ 100 consecutive residues predicted to be disordered. The error bars represent 95% confidence intervals and were calculated using 1,000 bootstrap re-sampling. Corresponding data for signaling and ordered proteins are shown for the comparison. Analyzed sets of diseas-related proteins included 1786, 487, 689, and 285 proteins for cancer, CVD, neurodegenerative disease and diabetes, respectively.
Dunker et al. BMC Genomics 2008 9(Suppl 2):S1 doi:10.1186/1471-2164-9-S2-S1