Amino acid alignments ferritin type I and type II from A. palmata, A. millepora, and N. vectensis with mouse H ferritin. Residues associated with the metal-binding site are written in uppercase bold. Tyr30, Tyr 33 and Tyr 35 that make up the ferroxidase center and Glu63 and His66 that play a role in polynuclear Fe-complex formation are uppercase bold and underlined. Tyr30 is specific for H ferritin in vertebrates [34,35]. Positively selected sites by a BEB procedure are lowercase bold, respectively lowercase bold and underlined if posterior probability of being in positively selected class > 0.5. Numbering is that of the mouse H chain sequence. Apal_Fer1: A. palmata ferritin type I, Amil_Fer1: A. millepora ferritin type I, Nv_Fer1: N. vectensis ferritin type I, Apal_Fer2: A. palmata ferritin type II, Amil_Fer2: A. millepora ferritin type II, Nv_Fer2: N. vectensis ferritin type II, MusFth1: mouse ferritin H chain.
Schwarz et al. BMC Genomics 2008 9:97 doi:10.1186/1471-2164-9-97