Large-scale analysis of Macaca fascicularis transcripts and inference of genetic divergence between M. fascicularis and M. mulatta

doi:10.1186/1471-2164-9-90

BMC Genomics

Volume 9

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Osada N
Hashimoto K
Kameoka Y
Hirata M
Tanuma R
Uno Y
Inoue I
Hida M
Suzuki Y
Sugano S
Terao K
Kusuda J
Takahashi I

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Osada N
Hashimoto K
Kameoka Y
Hirata M
Tanuma R
Uno Y
Inoue I
Hida M
Suzuki Y
Sugano S
Terao K
Kusuda J
Takahashi I
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Research article

Large-scale analysis of Macaca fascicularis transcripts and inference of genetic divergence between M. fascicularis and M. mulatta

Naoki Osada¹ , Katsuyuki Hashimoto¹ , Yosuke Kameoka¹ , Makoto Hirata¹ , Reiko Tanuma¹ , Yasuhiro Uno² , Itsuro Inoue³ , Munetomo Hida⁴ , Yutaka Suzuki⁵ , Sumio Sugano⁵ , Keiji Terao⁶ , Jun Kusuda¹ and Ichiro Takahashi¹

¹Department of Biomedical Resources, National Institute of Biomedical Innovation, Ibaraki, Japan

²Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Kainain, Japan

³Division of Genetic Diagnosis, Institute of Medical Science, University of Tokyo, Tokyo, Japan

⁴International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Tokyo, Japan

⁵Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan

⁶Tsukuba Primate Center for Medical Science, National Institute of Biomedical Innovation, Tsukuba, Japan

author email corresponding author email

BMC Genomics 2008, 9:90doi:10.1186/1471-2164-9-90


Published:	24 February 2008

Additional files

Additional file 1:

Expression of novel macaque transcripts. Significance of gene expression in the M. fascicularis oligonucleotide microarray analysis is shown.

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Additional file 2:

Unidentified UTR regions in the macaque cDNAs. The regions of macaque cDNAs that did not show homology to human cDNAs are listed.

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Additional file 3:

Divergence among the human, cynomolgus, and rhesus genes (dataset I: without a duplication filtering). Estimation of gene divergence using 2655 human-rhesus-cynomolgus alignment is shown.

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Additional file 4:

LRT (likelihood ratio test) statistics for the test of positive selection. Candidate genes under positive selection using branch-site test of positive selection are given with log-likelihood ratio.

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Additional file 5:

Specific probes for known genes in the M. fascicularis microarray. These genes are not found in the previously published macaque oligonucleotide microarray.

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Additional file 6:

Primer sequences for RT-PCR. The list shows the primer sequences that were used for RT-PCR.

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